NDUFS5

Across TCGA cell cohorts, NDUFS5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,691 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NDUFS5-associated GO terms across cancer lineages are mRNA splicing, via endonucleolytic cleavage and ligation, Negative regulation of protein export from nucleus, and Positive regulation of protein localization to plasma membrane. Each is linked with NDUFS5 in more than 9 cancer types. Because this analysis shows association rather than direction, both NDUFS5-to-partner and partner-to-NDUFS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splicing, via endonucleolytic cleavage and ligation grouped by NDUFS5-low versus NDUFS5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS5→partner) and Y-score (partner→NDUFS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	mRNA splicing, via endonucleolytic cleavage and ligation →	+0.137	+1.201	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein export from nucleus →	-0.122	-0.822	<.001	<.001	3	9
BONE	Positive regulation of protein localization to plasma membrane →	-0.090	-0.472	.001	.003	3	9
BONE	ERBB signaling pathway →	-0.100	-0.702	.001	.001	3	9
BLOOD_Leukemia	Mitochondrial translation →	+0.070	+0.722	<.001	<.001	3	8
BLOOD_Myeloma	ATF6-mediated unfolded protein response →	-0.134	-0.982	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,691 associations by consensus.

mRNA splicing, via endonucleolytic cleavage and ligation by NDUFS5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →