NDUFS5

Across TCGA pan-cancer cohorts, NDUFS5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFS5 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDUFS5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDUFS5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where NDUFS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.886	.002	43	view →
UCEC	OS	Tertile	All	1.000	0.862	.022	16	view →
PDAC	OS	Quartile	III,IV	0.864	0.240	.006	14	view →
HNSC	DFS	Quartile	II,III,IV	0.821	1.000	.001	11	view →
LUAD	DFS	Median	All	0.877	1.000	.005	6	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.538	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFS5–CCRCC (OS)

Open the CCRCC breakdown →