NCK interacting protein with SH3 domainGenealiases: AF3P21 · DIP · DIP1 · ORF1 · SPIN90 · VIP54
Q-omics provides the consensus-scored NCKIPSD profile across patient tissues and cancer cell-line models. NCKIPSD expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, NCKIPSD is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, NCKIPSD protein abundance shows 18,989 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, KIRC, and GBM as cancer lineages where NCKIPSD shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NCKIPSD — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NCKIPSD survival associations across molecular data types. NCKIPSD RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NCKIPSD RNA expression–survival associations across cancer types. High NCKIPSD expression shows unfavorable associations in KICH, LIHC and MESO, but favorable associations in UVM, KIRP and KIRC. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for NCKIPSD RNA expression.
This table summarizes NCKIPSD tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for NCKIPSD. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NCKIPSD shows higher tumor expression in KIRC, LIHC, HNSC, COAD, BLCA and LUAD. The KIRC box plot shows higher NCKIPSD RNA expression in tumor versus normal tissue (log2 FC = +0.661, t-test p < 0.001).
This table shows molecular features associated with NCKIPSD in patient tissues and cancer cell lines. In patient samples, NCKIPSD shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, NCKIPSD RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in SKIN and UPPER_AERODIGESTIVE_TRACT.
