MTHFD2L

Across TCGA patient cohorts, MTHFD2L mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFD2L-associated genes across cancer lineages are MIR6504, LINC01696, and HMGB1P25. Each is linked with MTHFD2L in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFD2L-to-partner and partner-to-MTHFD2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6504 grouped by MTHFD2L-low versus MTHFD2L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2L→partner) and Y-score (partner→MTHFD2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR6504 →	+0.421	+4.314	<.001	.009	3	2
CESC	LINC01696 →	+0.116	+4.760	<.001	<.001	3	2
CESC	HMGB1P25 →	+0.060	+4.201	<.001	.002	3	2
BLCA	ARF1P1 →	+0.053	+4.562	<.001	.006	3	2
BLCA	ACTR3P3 →	+0.034	+5.033	<.001	.003	3	2
UCEC	RPS17P1 →	+0.562	+3.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

MIR6504 by MTHFD2L expression — BLCA

Explore this box plot interactively →