Q-omics provides the consensus-scored HMGB1P25 profile across patient tissues and cancer cell-line models. HMGB1P25 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in THYM. Additionally, HMGB1P25 RNA expression shows 6,068 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight THYM, and STAD as cancer lineages where HMGB1P25 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for HMGB1P25 — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes HMGB1P25 survival associations across molecular data types. HMGB1P25 RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB1P25 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	16	THYM (96)	view →

This table ranks reproducible HMGB1P25 RNA expression–survival associations across cancer types. High HMGB1P25 expression shows unfavorable associations in THYM, DLBC, STAD and COAD, but favorable associations in UCS and BLCA. The THYM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THYM as the clearest survival context for HMGB1P25 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.604	0.975	<.001	96	view →
UCS	DFS	Tertile	II,III,IV	0.871	0.241	.001	84	view →
DLBC	DFS	Tertile	III,IV	0.111	0.775	<.001	72	view →
STAD	OS	Tertile	II,III,IV	0.245	0.637	.002	57	view →
BLCA	OS	Tertile	III,IV	1.000	0.236	.017	48	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →

Pink = unfavorable, green = favorable. all 16 lineages →

HMGB1P25-THYM (OS)

Kaplan–Meier survival curve for HMGB1P25 RNA expression in THYM: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB1P25 in patient tissues and cancer cell lines. In patient samples, HMGB1P25 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,068	STAD (5454)	view →
RNA	2,156	KIRC (651)	view →