HMGB1P25

Across TCGA patient cohorts, HMGB1P25 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,068 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P25-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Regulation of microtubule-based process, and Microtubule-based transport. Each is linked with HMGB1P25 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB1P25-to-partner and partner-to-HMGB1P25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by HMGB1P25-low versus HMGB1P25-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P25→partner) and Y-score (partner→HMGB1P25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of protein serine/threonine kinase activity →	+0.055	+0.090	<.001	<.001	3	9
STAD	Regulation of microtubule-based process →	+0.055	+0.116	<.001	<.001	3	9
STAD	Microtubule-based transport →	+0.053	+0.091	<.001	<.001	3	8
STAD	Protein autoubiquitination →	+0.065	+0.096	<.001	<.001	3	8
STAD	Positive regulation of telomerase activity →	+0.072	+0.106	<.001	<.001	3	8
STAD	Glycosylation →	+0.052	+0.088	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,068 associations by consensus.

Regulation of protein serine/threonine kinase activity by HMGB1P25 expression — STAD

Explore this box plot interactively →