Mov10 like RNA helicase 1Genealiases: CHAMP · DJ402G11.8 · SPGF73
Q-omics provides the consensus-scored MOV10L1 profile across patient tissues and cancer cell-line models. MOV10L1 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MOV10L1 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, MOV10L1 RNA expression shows 11,548 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight HNSC, and TGCT as cancer lineages where MOV10L1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MOV10L1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MOV10L1 survival associations across molecular data types. MOV10L1 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MOV10L1 RNA expression–survival associations across cancer types. High MOV10L1 expression shows unfavorable associations in UVM, KIRP and ACC, but favorable associations in HNSC, THCA and SKCM. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .007). Together, the overview and detailed table identify HNSC as the clearest survival context for MOV10L1 RNA expression.
This table summarizes MOV10L1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for MOV10L1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MOV10L1 shows lower tumor expression in UCEC and KIRP and higher tumor expression in HNSC, COAD, BLCA and KIRC. The HNSC box plot shows higher MOV10L1 RNA expression in tumor versus normal tissue (log2 FC = +0.287, t-test p < 0.001).
This table shows molecular features associated with MOV10L1 in patient tissues and cancer cell lines. In patient samples, MOV10L1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, MOV10L1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BONE and LARGE_INTESTINE.
