monocyte to macrophage differentiation associatedGenealiases: MMA · MMD1 · PAQR11
Q-omics provides the consensus-scored MMD profile across patient tissues and cancer cell-line models. MMD expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, MMD is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, MMD RNA expression shows 18,395 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, HNSC, and UVM as cancer lineages where MMD shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MMD — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MMD survival associations across molecular data types. MMD RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MMD RNA expression–survival associations across cancer types. High MMD expression shows unfavorable associations in KIRP, STAD, LIHC, HNSC and CESC, but favorable associations in COAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for MMD RNA expression.
This table summarizes MMD tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for MMD. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MMD shows lower tumor expression in BRCA and KICH and higher tumor expression in HNSC, KIRP, LUAD and LIHC. The HNSC box plot shows higher MMD RNA expression in tumor versus normal tissue (log2 FC = +1.775, t-test p < 0.001).
This table shows molecular features associated with MMD in patient tissues and cancer cell lines. In patient samples, MMD shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MMD RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
