MMD

Across TCGA patient cohorts, MMD mutation is significantly associated with the RNA expression of many other genes, with 1,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMD-associated genes across cancer lineages are RNU6-572P, RAB28P1, and TUBBP11. Each is linked with MMD in more than 1 cancer types. Because this analysis shows association rather than direction, both MMD-to-partner and partner-to-MMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-572P grouped by MMD-low versus MMD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMD→partner) and Y-score (partner→MMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-572P →	+0.442	+7.741	<.001	.009	3	2
BRCA	RAB28P1 →	+0.126	+6.878	<.001	<.001	3	2
BRCA	TUBBP11 →	+0.253	+5.786	<.001	.001	3	2
BRCA	LINC02436 →	+0.055	+4.941	<.001	.002	3	2
UCEC	RCN1P1 →	+0.080	+1.746	.009	.005	3	2
UCEC	EIF3JP1 →	+0.242	+2.105	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,832 associations by consensus.

RNU6-572P by MMD expression — COAD

Explore this box plot interactively →