MMD

Across TCGA patient cohorts, MMD mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMD-associated genes across cancer lineages are INPP4B, XRCC1, and ATM. Each is linked with MMD in more than 1 cancer types. Because this analysis shows association rather than direction, both MMD-to-partner and partner-to-MMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by MMD-low versus MMD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMD→partner) and Y-score (partner→MMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.344	-3.584	.015	.002	3	2
UCEC	XRCC1 →	+0.145	+2.321	.035	.034	3	2
UCEC	ATM →	-0.680	-2.459	<.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.337	-2.115	.002	.019	3	1
UCEC	Fibronectin →	-0.323	-2.115	.025	.019	3	1
UCEC	GATA6 →	-0.181	-2.985	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

INPP4B by MMD expression — UCEC

Explore this box plot interactively →