MMACHC

Across TCGA patient cohorts, MMACHC mutation is significantly associated with the RNA expression of many other genes, with 667 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMACHC-associated genes across cancer lineages are ARF4P3, MTND4P25, and RNU6-742P. Each is linked with MMACHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARF4P3 grouped by MMACHC-low versus MMACHC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ARF4P3 →	+0.079	+4.973	.003	.009	3	2
BLCA	MTND4P25 →	+0.248	+7.040	<.001	<.001	3	2
LIHC	RNU6-742P →	+0.309	+5.149	<.001	.003	3	2
UCEC	RPL32P6 →	+0.313	+2.411	<.001	<.001	3	2
SKCM	HINT1P2 →	+0.157	+5.436	<.001	.005	3	2
SKCM	MTND1P27 →	+0.042	+5.224	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 667 associations by consensus.

ARF4P3 by MMACHC expression — BLCA

Explore this box plot interactively →