MMACHC

Across TCGA pan-cancer cohorts, MMACHC RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MMACHC data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MMACHC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MMACHC expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

KICH, LGG, and READ are the cancer types where MMACHC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.737	1.000	.001	85	view →
LGG	DFS	Median	All	0.776	0.887	<.001	47	view →
READ	DFS	Median	All	0.724	0.407	.003	36	view →
KIRC	OS	Median	All	0.700	0.557	<.001	32	view →
SCLC	OS	Median	II,III,IV	0.795	0.461	.008	26	view →
BLCA	DFS	Tertile	IV	0.203	0.595	.002	24	view →
STAD	DFS	Quartile	II,III,IV	0.781	0.534	.004	20	view →
ACC	OS	Median	All	0.804	0.934	.007	19	view →
LAML	DFS	Quartile	All	0.443	0.717	.006	18	view →
COAD	OS	Median	III,IV	0.864	0.683	.010	17	view →
LUSC	DFS	Quartile	III,IV	0.484	0.961	.020	15	view →
UCEC	DFS	Median	All	0.803	0.871	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MMACHC–KICH (OS)

Open the KICH breakdown →