MMACHC

Across TCGA pan-cancer cohorts, MMACHC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MMACHC’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MMACHC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMACHC is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LUAD, LUSC, and BLCA are the cancer types where MMACHC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMACHC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.985	<.001	9	view →
LUSC	Female	II,III,IV	+1.494	<.001	8	view →
BLCA	All	All	+0.749	<.001	8	view →
THCA	Male	II,III,IV	−0.598	<.001	8	view →
STAD	Male	II,III,IV	+0.947	<.001	7	view →
COAD	Female	II,III,IV	+0.681	<.001	7	view →
KIRC	Male	All	−0.524	<.001	7	view →
UCEC	All	All	+0.743	<.001	6	view →
KIRP	Male	All	−0.530	<.001	6	view →
HNSC	All	III,IV	+0.412	.012	4	view →
KICH	Male	IV	−0.896	.018	3	view →
READ	Female	All	+0.588	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MMACHC–LUAD

Open the LUAD breakdown →