MKI67

Across TCGA patient cohorts, MKI67 mutation is significantly associated with the RNA expression of many other genes, with 8,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKI67-associated genes across cancer lineages are SENP3-EIF4A1, CACYBP, and RCC1. Each is linked with MKI67 in more than 4 cancer types. Because this analysis shows association rather than direction, both MKI67-to-partner and partner-to-MKI67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3-EIF4A1 grouped by MKI67-low versus MKI67-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKI67→partner) and Y-score (partner→MKI67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SENP3-EIF4A1 →	+0.203	+3.608	<.001	.001	3	5
SKCM	CACYBP →	+0.364	+1.701	.002	.005	3	5
STAD	RCC1 →	+0.718	+3.819	<.001	<.001	3	5
STAD	ACBD5 →	+0.865	+2.923	<.001	<.001	3	5
STAD	ATP5F1B →	+0.499	+2.906	.002	.001	3	5
STAD	GTF2A2 →	+0.613	+2.973	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,122 associations by consensus.

SENP3-EIF4A1 by MKI67 expression — STAD

Explore this box plot interactively →