MKI67

Across TCGA pan-cancer cohorts, MKI67 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MKI67 data layer compared with 12 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MKI67 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MKI67 expression acts as an unfavorable survival marker, although some lineages such as GBM and THYM show a favorable association.

ACC, KIRP, and MESO are the cancer types where MKI67 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.336	0.893	<.001	165	view →
KIRP	DFS	Median	All	0.758	0.941	<.001	149	view →
MESO	OS	Median	All	0.388	0.697	<.001	138	view →
UVM	DFS	Median	All	0.433	0.747	<.001	107	view →
LIHC	DFS	Median	All	0.446	0.634	<.001	94	view →
KICH	OS	Median	III,IV	0.363	0.957	<.001	88	view →
KIRC	DFS	Tertile	All	0.701	0.855	<.001	67	view →
LUAD	OS	Median	All	0.759	0.860	<.001	62	view →
LGG	OS	Median	All	0.738	0.884	<.001	48	view →
PAAD	OS	Median	All	0.288	0.496	<.001	44	view →
SARC	DFS	Median	All	0.535	0.683	<.001	35	view →
BLCA	DFS	Quartile	All	0.423	0.606	.001	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MKI67–ACC (OS)

Open the ACC breakdown →