MIR4435-2HG

Across TCGA patient cohorts, MIR4435-2HG mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIR4435-2HG-associated genes across cancer lineages are MIR6780B, RPL14P6, and RNA5SP205. Each is linked with MIR4435-2HG in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR4435-2HG-to-partner and partner-to-MIR4435-2HG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780B grouped by MIR4435-2HG-low versus MIR4435-2HG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4435-2HG→partner) and Y-score (partner→MIR4435-2HG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6780B →	+0.928	+5.889	<.001	<.001	3	1
UCEC	RPL14P6 →	+0.255	+3.847	.008	.008	3	1
UCEC	RNA5SP205 →	+0.351	+4.267	<.001	.009	3	1
UCEC	GOLGA6L11P →	+0.026	+5.292	<.001	.002	3	1
UCEC	SNX18P4 →	+0.060	+5.464	<.001	.001	3	1
UCEC	USP12PY →	+0.048	+4.641	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MIR6780B by MIR4435-2HG expression — UCEC

Explore this box plot interactively →