Q-omics provides the consensus-scored USP12PY profile across patient tissues and cancer cell-line models. USP12PY expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, USP12PY is differentially expressed in 5, with the highest sampling consensus in HNSC. Additionally, USP12PY RNA expression shows 6,422 significant gene co-expression associations, with the highest sampling consensus in UCEC. Together, these results highlight MESO, HNSC, and UCEC as cancer lineages where USP12PY shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP12PY — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP12PY survival associations across molecular data types. USP12PY RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP12PY RNA expression–survival associations across cancer types. High USP12PY expression shows unfavorable associations in MESO, ACC, THCA, LUSC and LGG, but favorable associations in COAD. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for USP12PY RNA expression.
This table summarizes USP12PY tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for USP12PY. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP12PY shows lower tumor expression in COAD, THCA and LUAD and higher tumor expression in HNSC and ESCA. The HNSC box plot shows higher USP12PY RNA expression in tumor versus normal tissue (log2 FC = +0.027, t-test p = .011).
This table shows molecular features associated with USP12PY in patient tissues and cancer cell lines. In patient samples, USP12PY shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set.
