USP12PY

Across TCGA pan-cancer cohorts, USP12PY RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of USP12PY’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where USP12PY RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP12PY is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, ESCA, and COAD are the cancer types where USP12PY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP12PY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.027	.011	6	view →
ESCA	All	II,III,IV	+0.055	.008	2	view →
COAD	Female	II,III,IV	−0.016	.034	2	view →
THCA	All	All	−0.009	.024	2	view →
LUAD	Female	II,III,IV	−0.032	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

USP12PY–HNSC

Open the HNSC breakdown →