USP12PY

Across TCGA pan-cancer cohorts, USP12PY RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated USP12PY data layer.

The strongest signal is observed in mesothelioma (MESO), where higher USP12PY RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USP12PY expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

MESO, ACC, and COAD are the cancer types where USP12PY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.083	0.575	<.001	99	view →
ACC	DFS	Tertile	All	0.137	0.673	.003	48	view →
COAD	OS	Tertile	IV	1.000	0.319	.012	39	view →
THCA	DFS	Tertile	IV	0.243	0.801	.021	36	view →
LUSC	DFS	Tertile	III,IV	0.010	0.754	<.001	36	view →
LGG	OS	Tertile	All	0.266	0.467	<.001	27	view →
LUAD	DFS	Tertile	All	0.928	0.652	.007	27	view →
PCPG	DFS	Tertile	All	0.088	0.869	.002	24	view →
PAAD	OS	Tertile	All	0.208	0.466	.021	18	view →
TGCT	OS	Tertile	II,III,IV	0.802	1.000	.040	18	view →
SARC	OS	Tertile	All	0.510	0.754	.005	18	view →
ESCA	DFS	Tertile	All	0.327	0.893	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

USP12PY–MESO (OS)

Open the MESO breakdown →