MIR4435-2HG

Across TCGA pan-cancer cohorts, MIR4435-2HG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MIR4435-2HG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR4435-2HG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4435-2HG is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where MIR4435-2HG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4435-2HG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.697	<.001	12	view →
HNSC	Male	III,IV	+1.247	<.001	12	view →
KIRP	All	III,IV	+1.648	<.001	11	view →
COAD	Male	III,IV	+1.443	<.001	11	view →
BLCA	Male	All	+1.134	<.001	11	view →
STAD	Male	III,IV	+1.971	<.001	10	view →
LIHC	Male	II,III,IV	+1.787	<.001	9	view →
LUAD	Male	II,III,IV	+1.260	<.001	9	view →
READ	All	II,III,IV	+2.217	<.001	7	view →
THCA	Male	All	+0.855	<.001	7	view →
BRCA	All	III,IV	+1.009	<.001	6	view →
UCEC	All	All	+0.903	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MIR4435-2HG–KIRC

Open the KIRC breakdown →