MIR4435-2HG

Across TCGA pan-cancer cohorts, MIR4435-2HG RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MIR4435-2HG data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MIR4435-2HG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR4435-2HG expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

UVM, KIRP, and ACC are the cancer types where MIR4435-2HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.550	0.921	<.001	129	view →
KIRP	DFS	Median	All	0.845	0.973	<.001	124	view →
ACC	DFS	Median	All	0.139	0.720	<.001	124	view →
HNSC	OS	Median	All	0.271	0.443	<.001	101	view →
BRCA	DFS	Quartile	All	0.849	0.931	.001	83	view →
MESO	OS	Median	All	0.266	0.513	<.001	71	view →
PAAD	DFS	Median	All	0.260	0.451	<.001	69	view →
LUAD	OS	Median	All	0.624	0.744	.001	56	view →
LIHC	OS	Median	All	0.421	0.590	<.001	55	view →
LGG	OS	Median	All	0.724	0.893	<.001	54	view →
BLCA	OS	Tertile	All	0.532	0.687	.001	42	view →
STAD	OS	Quartile	IV	0.256	0.744	.010	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MIR4435-2HG–UVM (DFS)

Open the UVM breakdown →