MIDN

Across TCGA cell cohorts, MIDN mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIDN-associated genes across cancer lineages are KSR2, SPACA5, and OTOS. Each is linked with MIDN in more than 1 cancer types. Because this analysis shows association rather than direction, both MIDN-to-partner and partner-to-MIDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by MIDN-low versus MIDN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDN→partner) and Y-score (partner→MIDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KSR2 →	+0.455	+3.502	.001	.001	3	2
BLOOD_Leukemia	SPACA5 →	+0.124	+3.745	.001	.005	3	1
BLOOD_Leukemia	OTOS →	+0.025	+3.969	<.001	.009	3	1
BLOOD_Leukemia	XKRX →	+0.227	+3.675	<.001	.005	3	1
BLOOD_Leukemia	KRTAP12-1 →	+0.056	+4.569	<.001	.003	3	1
BLOOD_Leukemia	KHDC3L →	+0.182	+3.774	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

KSR2 by MIDN expression — LARGE_INTESTINE

Explore this box plot interactively →