MIDN

Across TCGA pan-cancer cohorts, MIDN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MIDN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MIDN RNA is repressed in tumor relative to normal tissue. In most cancer types MIDN is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and BRCA are the cancer types where MIDN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIDN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−2.640	<.001	9	view →
BLCA	Female	IV	−2.306	<.001	6	view →
BRCA	All	All	+0.368	<.001	6	view →
CHOL	Male	All	+2.181	<.001	4	view →
LUSC	Male	II,III,IV	−0.580	.004	4	view →
STAD	Male	II,III,IV	+0.767	.025	2	view →
PAAD	Female	All	+0.564	.040	2	view →
LIHC	All	II,III,IV	+0.470	.038	2	view →
ESCA	All	All	+0.931	.037	1	view →
COAD	Female	All	−0.323	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MIDN–KICH

Open the KICH breakdown →