Q-omics provides the consensus-scored SPACA5 profile across patient tissues and cancer cell-line models. SPACA5 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, SPACA5 is differentially expressed in 2, with the highest sampling consensus in THCA. Additionally, SPACA5 RNA expression shows 9,161 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UCEC, THCA, and THYM as cancer lineages where SPACA5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPACA5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPACA5 survival associations across molecular data types. SPACA5 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPACA5 RNA expression–survival associations across cancer types. High SPACA5 expression shows unfavorable associations in UCEC, UVM, MESO, COAD and HNSC, but favorable associations in SCLC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UCEC as the clearest survival context for SPACA5 RNA expression.
This table summarizes SPACA5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for SPACA5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPACA5 shows lower tumor expression in THCA and higher tumor expression in BRCA. The THCA box plot shows higher SPACA5 RNA expression in normal versus tumor tissue (log2 FC = −0.073, t-test p = .046).
This table shows molecular features associated with SPACA5 in patient tissues and cancer cell lines. In patient samples, SPACA5 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SPACA5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma.
