SPACA5

Across TCGA pan-cancer cohorts, SPACA5 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SPACA5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPACA5 RNA is repressed in tumor relative to normal tissue. In most cancer types SPACA5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA and BRCA are the cancer types where SPACA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPACA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.073	.046	2	view →
BRCA	All	II,III,IV	+0.038	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SPACA5–THCA

Open the THCA breakdown →