SPACA5

Across TCGA pan-cancer cohorts, SPACA5 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SPACA5 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPACA5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPACA5 expression acts as an unfavorable survival marker, although some lineages such as SCLC and OV show a favorable association.

UCEC, UVM, and MESO are the cancer types where SPACA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	IV	0.349	0.764	.002	72	view →
UVM	DFS	Tertile	III,IV	0.272	0.813	.001	66	view →
MESO	DFS	Tertile	IV	0.073	0.381	<.001	63	view →
SCLC	OS	Tertile	All	0.953	0.648	.002	60	view →
COAD	DFS	Tertile	II,III,IV	0.466	0.696	.004	57	view →
HNSC	DFS	Tertile	IV	0.276	0.592	<.001	51	view →
OV	DFS	Tertile	All	0.447	0.351	.011	48	view →
KIRC	DFS	Quartile	IV	0.291	0.591	.002	35	view →
THCA	DFS	Tertile	IV	0.689	1.000	.010	18	view →
SKCM	OS	Tertile	IV	0.247	0.752	.004	18	view →
DLBC	OS	Tertile	IV	0.147	0.850	.002	18	view →
READ	OS	Tertile	III,IV	0.383	0.717	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SPACA5–UCEC (OS)

Open the UCEC breakdown →