Q-omics provides the consensus-scored MAGEA3 profile across patient tissues and cancer cell-line models. MAGEA3 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MAGEA3 is differentially expressed in 7, with the highest sampling consensus in HNSC. Additionally, MAGEA3 RNA expression shows 7,459 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, HNSC, and TGCT as cancer lineages where MAGEA3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAGEA3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAGEA3 survival associations across molecular data types. MAGEA3 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAGEA3 RNA expression–survival associations across cancer types. High MAGEA3 expression shows unfavorable associations in KIRC, KIRP, MESO, KICH, ACC and UCEC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MAGEA3 RNA expression.
This table summarizes MAGEA3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MAGEA3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAGEA3 shows higher tumor expression in HNSC, BLCA, LUAD, LUSC, LIHC and BRCA. The HNSC box plot shows higher MAGEA3 RNA expression in tumor versus normal tissue (log2 FC = +3.172, t-test p < 0.001).
This table shows molecular features associated with MAGEA3 in patient tissues and cancer cell lines. In patient samples, MAGEA3 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, MAGEA3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in OVARY and SKIN.
