Across TCGA patient cohorts, MAGEA3 mutation is significantly associated with the RNA expression of many other genes, with 4,244 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEA3-associated genes across cancer lineages are RNU7-176P, C8orf44-SGK3, and H2BC2P. Each is linked with MAGEA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEA3-to-partner and partner-to-MAGEA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA3→partner) and Y-score (partner→MAGEA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-176P →	+0.925	+5.015	<.001	.009	3	3
UCEC	C8orf44-SGK3 →	+0.041	+1.545	.007	.004	3	3
HNSC	H2BC2P →	+0.137	+6.339	<.001	.001	3	2
COAD	RN7SL134P →	+0.099	+3.374	.006	.008	3	2
COAD	RPL22P6 →	+0.071	+4.399	<.001	.006	3	2
UCEC	FCGR1A →	+0.741	+2.544	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,244 associations by consensus.

Exploration

MAGEA3 survival (RNA) · tumor vs normal (RNA) · all MAGEA3 data types