M6PR

Across TCGA patient cohorts, M6PR mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible M6PR-associated genes across cancer lineages are MIR4510, RN7SL163P, and VN1R93P. Each is linked with M6PR in more than 1 cancer types. Because this analysis shows association rather than direction, both M6PR-to-partner and partner-to-M6PR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by M6PR-low versus M6PR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (M6PR→partner) and Y-score (partner→M6PR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4510 →	+0.251	+4.132	<.001	.009	3	1
UCEC	RN7SL163P →	+0.283	+3.179	<.001	.006	3	1
UCEC	VN1R93P →	+0.298	+4.673	<.001	<.001	3	1
LUSC	RNU6-650P →	+0.618	+5.093	<.001	.008	3	1
LUSC	RNU6-331P →	+0.419	+5.706	<.001	.003	3	1
LUSC	MT-TA →	+0.587	+5.404	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MIR4510 by M6PR expression — UCEC

Explore this box plot interactively →