M6PR

Across TCGA pan-cancer cohorts, M6PR RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of M6PR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where M6PR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types M6PR is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where M6PR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in M6PR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.013	<.001	11	view →
COAD	Female	All	+0.694	<.001	11	view →
BLCA	All	III,IV	+0.887	<.001	10	view →
KIRP	All	II,III,IV	+0.801	.001	7	view →
STAD	Male	II,III,IV	+0.892	<.001	6	view →
THCA	All	All	−0.457	.006	6	view →
CHOL	All	All	+1.880	<.001	5	view →
ESCA	All	All	+0.786	.011	4	view →
LIHC	Female	All	+0.670	.005	4	view →
KIRC	Male	All	+0.398	<.001	4	view →
BRCA	All	II,III,IV	+0.275	<.001	4	view →
PRAD	All	All	−0.316	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

M6PR–HNSC

Open the HNSC breakdown →