LRRC38

Across TCGA patient cohorts, LRRC38 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LRRC38-associated genes across cancer lineages are RNU6-42P, RNU6-49P, and RNU1-2. Each is linked with LRRC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC38-to-partner and partner-to-LRRC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-42P grouped by LRRC38-low versus LRRC38-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC38→partner) and Y-score (partner→LRRC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-42P →	+1.286	+3.842	<.001	.005	3	2
COAD	RNU6-49P →	+0.188	+4.721	<.001	.004	3	2
COAD	RNU1-2 →	+1.192	+3.242	<.001	.009	3	2
COAD	RNU2-61P →	+1.169	+4.251	<.001	.008	3	2
COAD	TMPRSS11GP →	+0.093	+4.283	.003	.001	3	2
COAD	RPS29P7 →	+0.535	+3.266	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

RNU6-42P by LRRC38 expression — COAD

Explore this box plot interactively →