Q-omics provides the consensus-scored RNU6-42P profile across patient tissues and cancer cell-line models. RNU6-42P expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, RNU6-42P is differentially expressed in 5, with the highest sampling consensus in UCEC. Additionally, RNU6-42P RNA expression shows 5,638 significant pathway-activity associations, with the highest sampling consensus in KIRC. Together, these results highlight LIHC, UCEC, and KIRC as cancer lineages where RNU6-42P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-42P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-42P survival associations across molecular data types. RNU6-42P RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-42P RNA expression–survival associations across cancer types. High RNU6-42P expression shows unfavorable associations in LIHC, HNSC and READ, but favorable associations in CESC, PAAD and LUSC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify LIHC as the clearest survival context for RNU6-42P RNA expression.
This table summarizes RNU6-42P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in UCEC for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-42P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-42P shows lower tumor expression in KIRC and higher tumor expression in UCEC, LUAD, STAD and LUSC. The UCEC box plot shows higher RNU6-42P RNA expression in tumor versus normal tissue (log2 FC = +0.802, t-test p = .001).
This table shows molecular features associated with RNU6-42P in patient tissues and cancer cell lines. In patient samples, RNU6-42P shows the broadest associations at the RNA and protein expression levels, with KIRC recurring as the lineage with the largest associated feature set.
