Across TCGA pan-cancer cohorts, RNU6-42P RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RNU6-42P data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RNU6-42P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-42P expression acts as an unfavorable survival marker, although some lineages such as CESC and PAAD show a favorable association.

LIHC, HNSC, and CESC are the cancer types where RNU6-42P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.407	0.659	.003	60	view →
HNSC	DFS	Tertile	IV	0.397	0.581	.002	48	view →
CESC	DFS	Tertile	II,III,IV	0.827	0.364	.012	42	view →
PAAD	OS	Tertile	II,III,IV	0.639	0.304	.016	36	view →
LUSC	DFS	Tertile	II,III,IV	0.823	0.344	.001	31	view →
READ	OS	Tertile	IV	0.628	0.966	.016	24	view →
ACC	DFS	Tertile	All	0.196	0.618	.002	18	view →
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	14	view →
BLCA	OS	Tertile	All	0.818	0.629	.037	14	view →
ESCA	OS	Tertile	IV	0.916	0.219	.024	12	view →
COAD	DFS	Tertile	III,IV	0.300	0.586	.001	9	view →
THCA	DFS	Tertile	III,IV	0.805	0.942	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: RNU6-42P tumor-vs-normal RNA expression · all RNU6-42P data types