Across TCGA pan-cancer cohorts, RNU6-42P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-42P’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RNU6-42P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-42P is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
UCEC, LUAD, and STAD are the cancer types where RNU6-42P tumor–normal differential expression is most reproducible.