LRRC38

Across TCGA pan-cancer cohorts, LRRC38 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LRRC38’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRRC38 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC38 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and BLCA are the cancer types where LRRC38 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC38 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.202	<.001	9	view →
BRCA	Female	II,III,IV	−0.450	<.001	8	view →
BLCA	All	All	−0.328	.004	7	view →
COAD	All	All	+0.061	.006	5	view →
LUSC	All	All	+0.485	<.001	3	view →
STAD	All	All	−0.195	.006	3	view →
UCEC	All	All	−0.224	.001	2	view →
PRAD	All	All	−0.083	.012	2	view →
HNSC	Male	All	−0.550	.048	1	view →
KICH	Female	All	−0.460	.024	1	view →
KIRP	Male	All	−0.107	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LRRC38–KIRC

Open the KIRC breakdown →