LRRC38

Across TCGA pan-cancer cohorts, LRRC38 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LRRC38 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LRRC38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC38 expression acts as an unfavorable survival marker, although some lineages such as CESC and LGG show a favorable association.

KIRP, ACC, and HNSC are the cancer types where LRRC38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.791	0.924	<.001	103	view →
ACC	DFS	Median	All	0.233	0.691	<.001	101	view →
HNSC	DFS	Median	All	0.534	0.665	<.001	97	view →
KICH	DFS	Quartile	III,IV	0.221	0.848	.001	64	view →
LIHC	OS	Tertile	All	0.548	0.754	<.001	60	view →
CESC	DFS	Tertile	IV	0.796	0.321	.005	46	view →
LGG	DFS	Tertile	All	0.556	0.384	.004	28	view →
DLBC	DFS	Median	All	0.908	0.436	.008	28	view →
MESO	DFS	Tertile	All	0.827	0.197	.001	27	view →
UVM	OS	Tertile	III,IV	0.241	0.758	.023	21	view →
THYM	OS	Median	All	1.000	0.744	.001	18	view →
READ	DFS	Tertile	II,III,IV	0.931	0.656	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LRRC38–KIRP (OS)

Open the KIRP breakdown →