Q-omics provides the consensus-scored TMPRSS11GP profile across patient tissues and cancer cell-line models. TMPRSS11GP expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in THYM. Among the 18 cancer types available for tumor–normal comparison, TMPRSS11GP is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, TMPRSS11GP RNA expression shows 11,023 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight THYM, HNSC, and LSCC as cancer lineages where TMPRSS11GP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMPRSS11GP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMPRSS11GP survival associations across molecular data types. TMPRSS11GP RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMPRSS11GP RNA expression–survival associations across cancer types. High TMPRSS11GP expression shows unfavorable associations in THYM, UVM, CHOL and COAD, but favorable associations in LUSC and CESC. The THYM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .006). Together, the overview and detailed table identify THYM as the clearest survival context for TMPRSS11GP RNA expression.
This table summarizes TMPRSS11GP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for TMPRSS11GP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMPRSS11GP shows lower tumor expression in HNSC and higher tumor expression in LUSC, UCEC and LUAD. The HNSC box plot shows higher TMPRSS11GP RNA expression in normal versus tumor tissue (log2 FC = −0.549, t-test p < 0.001).
This table shows molecular features associated with TMPRSS11GP in patient tissues and cancer cell lines. In patient samples, TMPRSS11GP shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
