Across TCGA pan-cancer cohorts, TMPRSS11GP RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMPRSS11GP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPRSS11GP RNA is repressed in tumor relative to normal tissue. In most cancer types TMPRSS11GP is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LUSC, and UCEC are the cancer types where TMPRSS11GP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPRSS11GP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.549	<.001	10	view →
LUSC	Male	All	+0.472	<.001	6	view →
UCEC	All	All	+0.031	.011	2	view →
LUAD	All	All	+0.157	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMPRSS11GP RNA expression & survival · all TMPRSS11GP data types