long intergenic non-protein coding RNA 477Genealiases: C12orf67 · FAM191B
Q-omics provides the consensus-scored LINC00477 profile across patient tissues and cancer cell-line models. LINC00477 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, LINC00477 is differentially expressed in 3, with the highest sampling consensus in KIRC. Additionally, LINC00477 RNA expression shows 6,508 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight ACC, KIRC, and STAD as cancer lineages where LINC00477 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00477 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00477 survival associations across molecular data types. LINC00477 RNA expression shows survival associations in the most cancer types (14), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00477 RNA expression–survival associations across cancer types. High LINC00477 expression shows unfavorable associations in ACC, KIRC, LIHC, DLBC, COAD and LGG. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify ACC as the clearest survival context for LINC00477 RNA expression.
This table summarizes LINC00477 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00477. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00477 shows higher tumor expression in KIRC, ESCA and LUAD. The KIRC box plot shows higher LINC00477 RNA expression in tumor versus normal tissue (log2 FC = +0.010, t-test p = .004).
This table shows molecular features associated with LINC00477 in patient tissues and cancer cell lines. In patient samples, LINC00477 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
