LAMC1

Across TCGA patient cohorts, LAMC1 mutation is significantly associated with the RNA expression of many other genes, with 1,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMC1-associated genes across cancer lineages are TYMSOS, RNASEK, and ATP2A1-AS1. Each is linked with LAMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMC1-to-partner and partner-to-LAMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSOS grouped by LAMC1-low versus LAMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC1→partner) and Y-score (partner→LAMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMSOS →	+0.643	+2.403	<.001	<.001	3	3
UCEC	RNASEK →	+0.320	+1.981	<.001	<.001	3	3
UCEC	ATP2A1-AS1 →	+0.468	+1.776	.003	.007	3	3
LUSC	OR8D1 →	+0.294	+1.859	<.001	.005	3	3
UCEC	WRAP53 →	+0.303	+1.275	.005	.004	3	3
LIHC	TFAMP1 →	+0.080	+4.793	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,198 associations by consensus.

TYMSOS by LAMC1 expression — UCEC

Explore this box plot interactively →