LAMC1

Across TCGA pan-cancer cohorts, LAMC1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated LAMC1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LAMC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LAMC1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

BLCA, UVM, and MESO are the cancer types where LAMC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.344	0.499	<.001	154	view →
UVM	DFS	Median	All	0.427	0.741	<.001	117	view →
MESO	OS	Median	All	0.239	0.532	<.001	105	view →
ACC	DFS	Median	All	0.254	0.622	<.001	104	view →
STAD	OS	Tertile	All	0.485	0.677	.004	57	view →
LGG	OS	Median	All	0.716	0.908	<.001	54	view →
KIRP	DFS	Quartile	All	0.749	0.935	.001	54	view →
KICH	OS	Quartile	All	0.682	1.000	.011	46	view →
KIRC	OS	Median	All	0.711	0.549	<.001	38	view →
CESC	DFS	Median	All	0.770	0.876	.001	34	view →
LIHC	OS	Quartile	All	0.700	0.879	.001	33	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

LAMC1–BLCA (OS)

Open the BLCA breakdown →