LAMC1

Across TCGA pan-cancer cohorts, LAMC1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LAMC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LAMC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LAMC1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where LAMC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LAMC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.513	<.001	12	view →
KIRC	Female	All	+1.065	<.001	12	view →
KIRP	All	II,III,IV	+1.854	<.001	11	view →
LIHC	Female	II,III,IV	+2.419	<.001	9	view →
BRCA	All	All	−0.835	<.001	6	view →
LUAD	All	All	+0.408	.001	6	view →
BLCA	Male	IV	−1.380	.005	4	view →
CHOL	Male	All	+4.250	<.001	3	view →
ESCA	All	All	+1.143	.011	2	view →
KICH	All	All	−0.761	.004	2	view →
LUSC	All	All	+0.410	.011	2	view →
THCA	All	All	+0.268	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LAMC1–HNSC

Open the HNSC breakdown →