KRTAP5-8

Across TCGA patient cohorts, KRTAP5-8 mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-8-associated genes across cancer lineages are RPL7AP23, ETFA, and TEX36. Each is linked with KRTAP5-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-8-to-partner and partner-to-KRTAP5-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7AP23 grouped by KRTAP5-8-low versus KRTAP5-8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-8→partner) and Y-score (partner→KRTAP5-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL7AP23 →	+0.060	+5.103	<.001	.008	3	2
UCEC	ETFA →	+0.646	+3.201	.003	.009	3	2
SKCM	TEX36 →	+0.252	+3.188	<.001	.002	3	2
SKCM	RNU6-38P →	+0.163	+5.225	<.001	.001	3	2
SKCM	RANP5 →	+0.074	+2.872	.001	.006	3	2
UCEC	MIR7845 →	+0.449	+2.352	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

RPL7AP23 by KRTAP5-8 expression — CESC

Explore this box plot interactively →