KRTAP5-8

Across TCGA pan-cancer cohorts, KRTAP5-8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KRTAP5-8 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP5-8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KRTAP5-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and KIRC are the cancer types where KRTAP5-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.821	0.676	.002	67	view →
MESO	OS	Tertile	III,IV	0.668	0.343	<.001	50	view →
KIRC	DFS	Median	IV	0.411	0.581	.009	42	view →
BLCA	OS	Median	All	0.784	0.655	.001	40	view →
LUAD	OS	Tertile	II,III,IV	0.603	0.808	.002	30	view →
KIRP	DFS	Tertile	IV	0.040	0.683	.010	21	view →
CESC	OS	Tertile	IV	0.738	0.260	.006	18	view →
UVM	DFS	Tertile	II,III,IV	0.567	0.784	.021	18	view →
DLBC	DFS	Quartile	II,III,IV	0.124	0.951	.008	18	view →
SCLC	DFS	Median	II,III,IV	0.778	0.245	.004	17	view →
SARC	DFS	Quartile	All	0.780	0.500	.007	11	view →
SKCM	DFS	Tertile	IV	0.061	0.513	.033	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KRTAP5-8–HNSC (OS)

Open the HNSC breakdown →