KRTAP5-8

Across TCGA pan-cancer cohorts, KRTAP5-8 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KRTAP5-8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KRTAP5-8 RNA is repressed in tumor relative to normal tissue. In most cancer types KRTAP5-8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where KRTAP5-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRTAP5-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.998	<.001	12	view →
KIRP	Female	All	−1.271	<.001	11	view →
KICH	Female	II,III,IV	+3.400	<.001	8	view →
BRCA	All	II,III,IV	+0.078	<.001	6	view →
STAD	Male	II,III,IV	+0.114	.016	2	view →
PRAD	All	All	−0.050	.018	2	view →
COAD	Female	IV	+0.210	.011	1	view →
THCA	All	All	+0.050	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KRTAP5-8–KIRC

Open the KIRC breakdown →