Q-omics provides the consensus-scored KISS1R profile across patient tissues and cancer cell-line models. KISS1R expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in THYM. Among the 18 cancer types available for tumor–normal comparison, KISS1R is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, KISS1R RNA expression shows 13,004 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight THYM, KIRC, and TGCT as cancer lineages where KISS1R shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KISS1R — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KISS1R survival associations across molecular data types. KISS1R RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KISS1R RNA expression–survival associations across cancer types. High KISS1R expression shows unfavorable associations in THYM, UVM, UCS and KIRP, but favorable associations in STAD and KIRC. The THYM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THYM as the clearest survival context for KISS1R RNA expression.
This table summarizes KISS1R tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for KISS1R. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KISS1R shows higher tumor expression in KIRC, THCA, LUAD, HNSC, LUSC and UCEC. The KIRC box plot shows higher KISS1R RNA expression in tumor versus normal tissue (log2 FC = +2.863, t-test p < 0.001).
This table shows molecular features associated with KISS1R in patient tissues and cancer cell lines. In patient samples, KISS1R shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, KISS1R RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
