KISS1R

Across TCGA cell cohorts, KISS1R mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KISS1R-associated genes across cancer lineages are CCT8L2, USP29, and ALPI. Each is linked with KISS1R in more than 1 cancer types. Because this analysis shows association rather than direction, both KISS1R-to-partner and partner-to-KISS1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT8L2 grouped by KISS1R-low versus KISS1R-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KISS1R→partner) and Y-score (partner→KISS1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCT8L2 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ALPI →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP12-2 →	+0.096	+5.969	<.001	.001	3	1
LARGE_INTESTINE	NPHS2 →	+0.073	+4.029	.009	.009	3	1
LARGE_INTESTINE	RXFP2 →	+0.032	+3.684	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CCT8L2 by KISS1R expression — LUNG_SCLC

Explore this box plot interactively →