KISS1R

Across TCGA pan-cancer cohorts, KISS1R RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KISS1R data layer.

The strongest signal is observed in thymoma (THYM), where higher KISS1R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KISS1R expression acts as an unfavorable survival marker, although some lineages such as STAD and KIRC show a favorable association.

THYM, UVM, and UCS are the cancer types where KISS1R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	II,III,IV	0.534	0.917	<.001	69	view →
UVM	DFS	Median	All	0.322	0.650	<.001	64	view →
UCS	DFS	Median	II,III,IV	0.148	0.548	.002	60	view →
STAD	OS	Quartile	IV	0.529	0.128	.001	39	view →
KIRC	DFS	Median	IV	0.435	0.236	.007	24	view →
KIRP	DFS	Tertile	All	0.761	0.906	.003	22	view →
ACC	DFS	Median	All	0.234	0.613	.003	21	view →
COAD	DFS	Tertile	II,III,IV	0.403	0.818	.001	19	view →
THCA	DFS	Quartile	IV	0.374	0.886	.002	16	view →
PRAD	DFS	Quartile	All	0.903	0.972	.004	14	view →
ESCA	DFS	Median	All	0.911	0.331	.012	12	view →
LGG	DFS	Median	All	0.681	0.787	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KISS1R–THYM (DFS)

Open the THYM breakdown →