Across TCGA patient cohorts, KHDC3L mutation is significantly associated with the RNA expression of many other genes, with 685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDC3L-associated genes across cancer lineages are KRTAP1-4, RNU6-13P, and RN7SL508P. Each is linked with KHDC3L in more than 2 cancer types. Because this analysis shows association rather than direction, both KHDC3L-to-partner and partner-to-KHDC3L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC3L→partner) and Y-score (partner→KHDC3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	KRTAP1-4 →	+0.215	+5.219	<.001	.006	3	3
READ	RNU6-13P →	+0.631	+5.039	<.001	.008	3	3
UCEC	RN7SL508P →	+0.171	+2.308	.009	.002	3	3
COAD	RNU6-503P →	+0.267	+6.156	<.001	<.001	3	3
BRCA	OR10G8 →	+0.167	+5.711	<.001	.001	3	3
UCEC	CIDECP1 →	+0.560	+2.860	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 685 associations by consensus.

Exploration

KHDC3L survival (RNA) · tumor vs normal (RNA) · all KHDC3L data types