Across TCGA pan-cancer cohorts, KHDC3L RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KHDC3L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KHDC3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KHDC3L is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, BRCA, and LUAD are the cancer types where KHDC3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KHDC3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.104	.017	6	view →
BRCA	All	All	−0.089	<.001	4	view →
LUAD	All	III,IV	−0.041	.018	2	view →
KIRC	Male	All	+0.019	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KHDC3L RNA expression & survival · all KHDC3L data types